Angelman syndrome (AS) is an inherited disorder characterized by intellectual disability, speech impairment, seizures, and movement and balance problems. Babies affected with AS appear normal at birth. Around 6-12 months delays begin to be noticed in learning to walk or talk and a diagnosis can be made. Seizures typically begin around 2-3 years of age. Affected children usually have a very happy disposition. They can also be hyperactive and have difficulty sleeping. As they age, the hyperactivity and sleeping issues will sometimes improve. Life expectancy is normal, though independent living is not possible for adults with AS. There is no cure for AS. Pathogenic variants in the UBE3A gene is one of the causes of AS.