Infantile neuroaxonal dystrophy (INAD) 1 is a rare inherited disorder that affects the nervous system. Symptoms typically begin to appear between six months and three years of age. A baby's motor development will start out normally and then begin to slow down. The ability to walk may be delayed and then lost. Muscle control at first will be weak and floppy and then become stiff. The lack of muscle control causes breathing problems that often leads to frequent infections. Mental capacity also deteriorates to a point that children affected with INAD 1 become unaware of their surroundings. Vision and hearing loss are also common in affected children. Death usually occurs before 10 years of age, though some individuals have survived into their teens. There is no cure for INAD 1, but medical surveillance and care may help to improve some symptoms and overall condition of life. INAD 1 is caused by pathogenic variants in the PLA2G6 gene.