Ataxia with vitamin E deficiency (AVED) is an inherited disorder that affects the body's ability to utilize vitamin E. This condition will lead to difficulty coordinating movements, clumsiness of the hands, loss of reflexes in legs and sensation in extremities, and blurred vision. Most affected individual start to experience problems with movement between the age of 4 and 18 years, which will worsen with age. In some cases, the cognitive ability of the affected individuals may decline. If untreated, affected individuals become wheelchair bound between ages of 11 and 50 years as a result of lack of muscle control and/or leg weakness. The life expectancy of individuals with AVED may be shortened. AVED can be treated with vitamin E supplementation, which can reverse some symptoms if treatment is initiated during the progress of the disease, or prevent symptoms altogether if initiated before symptoms appear. AVED is caused by pathogenic variants in the TTPA gene.