PROP1-related combined pituitary hormone deficiency (CPHD) is an inherited disorder caused by deficiency of several hormones in the body. Absence of these hormones affects many parts of the body. Children affected by this condition have poor growth and short stature. They often develop hypothyroidism which can result in weight gain and fatigue. Affected individuals can also experience delayed or absent puberty and some individuals can suffer from infertility. Intellectual disability is rare. There is no cure for CPHD, but replacement therapy for the appropriate hormones can help to improve or reverse onset of symptoms. Life expectancy is normal for individuals with CPHD. One of the causes of CPHD is pathogenic variants in the PROP1 gene.