Neuronal Ceroid-Lipofuscinosis (NCL) is an inherited disease that affects neural systems. Patients with this disorder may have gradual loss of previously acquired skills, intellectual disability, behavioral problems, vision impairment, seizure and early death. NCL patients have been characterized traditionally according to the age of onset and order of appearance of clinical features into infantile, late-infantile, juvenile and adult types. Individuals with this condition often require the use of a wheelchair by late childhood and typically do not survive past their teens. Pathogenic variants in more than 10 genes can cause NCL and the most common genes include TPP1, PPT1, CLN3, CLN5, CLN6 and CLN8. Pathogenic variants in the CLN5 gene are the major cause of late infantile NCL.