Bardet-Biedl syndrome (BBS) is an inherited disorder that affects various parts of the body. Individuals affected by BBS typically have vision loss, obesity, extra digits, kidney disease, intellectual disability or learning difficulties, and abnormalities of the genitalia. The onset and symptoms can vary among affected individuals. Typically, night blindness occurs around 7 to 8 years and progresses to blindness in adolescence or early adulthood. Kidney disease can progress to renal failure, which has a significant effect on life expectancy. There is no specific treatment available but medical surveillance and care may help to improve some symptoms and overall condition of life. BBS is caused by pathogenic variants in 14 different genes, often collectively called the BBS genes.